A in the current issue of the journal JAMA addresses breast and prostate cancer screening and the complexities and limitations of current screening approaches. The authors explain that while screening for the two diseases has increased, “the absolute numbers of read advanced disease have not decreased nearly as much as hoped for either cancer,” and that mortality has not decreased as much as expected.
It’s a complicated topic, even without getting into issues of access to screening and racial disparities in screening and treatment (which the JAMA piece does not). Essentially, the key limitations of screening are that widespread screening with current methods may sometimes detect slow-growing or inconsequential tumors, resulting in unnecessary treatment (because it’s not yet possible to predict which tumors present little risk), while in other cases, early detection doesn’t decrease mortality rates, because certain aggressive cancers, even when caught early, will not respond to treatment.
These messages are not easy message to convey or understand, and some worry that the related headlines may lead people to think screening is unwarranted. In on the commentary one biostatistician expressed concern that “the complex view of a changing landscape will be distilled by the public into yet another ‘screening does not work’ headline. The fact that population screening is no panacea does not mean that it is useless.”
The authors of the JAMA commentary don’t propose abandonment of breast and prostate cancer screening, however – they propose an improved approach consisting of determining validation tools that can identify and differentiate high and low risk cancers, reduction of treatment for minimal-risk disease, improved clinical and patient support tools to help guide decision-making, and identification of the the highest-risk patients for prevention initiatives. They suggest that there should be investment of significant funds – perhaps 10-20% of the $20 billion spent each year on screening – in these four areas “to improve screening, accelerate prevention research, and reduce harm from breast cancer and prostate cancer deaths.”
The New York Times article on the commentary also generated some controversy when it characterized the American Cancer’s Society’s response to the commentary as “saying that the benefits of detecting many cancers, especially breast and prostate, have been overstated” and that the organization was as a result “reconsider[in] its message about the risks as well as potential benefits of screening.”
The American Cancer Society has issued multiple responses to this characterization, explaining that it is standing by its screening guidelines. Organization representatives stated that they have long acknowledged that cancer screening isn’t perfect, but that “The bottom line is that mammography has helped avert deaths from breast cancer, and we can make read progress against the disease if read women age 40 and older get an annual mammogram.”
However, this research adds read fodder to the question of whether and how effective mammograms are. The Cochrane Collaboration, which creates meta-analysis of high quality systematic reviews, states in its review that while screening likely reduces breast cancer mortality, ” it is not clear whether screening does read good than harm.”